Extraction and Fungal PCR Kits

PathoNosticsⓇ offers a broad range of diagnostic CE-IVD kits for the diagnosis of fungal infections with the mission to detect and differentiate the disease causing fungus and simultaneously detect resistance, which allows doctors to initiate a dedicated therapy promptly and save on costs and lives. PathoNosticsⓇ assays advance the diagnosis of both superficial and invasive fungal infections and allow antifungal therapy to be more appropriately targeted.

Key Features and Benefits
  • Multiplex Precision
  • Results in 3 hours
  • Comprehensive panels
  • Superior specificity, sensitivity & accuracy
  • EU-IVD Certified

AsperGenius®

Features and benefits

  • Aids in the diagnosis of Invasive Aspergillosis (IA)
  • Differentiation of A. fumigatus, A. flavus (PN-101 only), A. terreus (in PN-101 only in Rotor-Gene Q and CFX96) and A. species
  • Identification of most prevalent azole-resistant markers in A. fumigatus: TR34 and TR46
  • Fast sample-to-result
  • Companion diagnostic strategy with galactomannan (high sensitivity and specificity)
  • Validated on organ transplant/hematology/Intensive Care patient cohorts
  • Allows for timely, targeted antifungal treatment resulting in improved clinical outcome

AsperGenius® 2.0 Species Multiplex real-time PCR kit (50 rxn) (Cat No.: PN-101)

Targets

  • Aspergillus fumigatus
  • Aspergillus flavus
  • Aspergillus species
  • Internal Control (IC)
  • Aspergillus terreus (only on Rotor-Gene Q and CFX96)

AsperGenius® 2.0 Resistance TR Multiplex real-time PCR kit (50 rxn) Resistance TR multiplex (Cat No.: PN-201)

Targets

  • Aspergillus fumigatus TR34
  • Aspergillus fumigatus TR46
  • Aspergillus fumigatus cyp51A (WT)
  • Internal Control (IC)

DermaGenius®

Features and benefits

  • Aids in the diagnosis of dermatophytosis (superficial fungal infections)
  • Detects > 95% of the clinically most relevant dermatophytes
  • Dermatophyte species identification, enabling: Targeted treatment
  • Detection of mutations in the squalene epoxidase (SQLE) gene (Drug resistance)
  • Differentiation between wildtype and resistant SQLE strains (Drug resistance)
  • Detection in nail, skin and hair samples
  • Sample-to-result in less than 3 hours
  • Higher sensitivity: up to 20% more positive results compared to culture
  • Identification of source of infection
  • Assistance in outbreak management
  • Including Pan-dermatophyte mix

DermaGenius® 3.0 Nail Multiplex real-time PCR kit (50 rxn)  (Cat No.: PN-302)

Targets

  • ‍Trichophyton rubrum
  • Trichophyton interdigitale
  • Candida albicans
  • Candida parapsilosis
  • Scopulariopsis brevicaulis
  • Internal control

DermaGenius® 2.0/3.0 Complete Multiplex real-time PCR kit (50 rxn) (Cat No.: PN-401/402)

Targets

  • Trichophyton rubrum / Trichophyton soudanense
  • Trichophyton interdigitale / Trichophyton mentagrophytes
  • Trichophyton tonsurans
  • Trichophyton schoenleinii / Trichophyton quinckeanum
  • Trichophyton violaceum
  • Trichophyton benhamiae
  • Trichophyton verrucosum
  • Microsporum canis
  • Microsporum audouinii
  • Nannizzia gypsea*
  • Epidermophyton floccosum
  • Candida albicans
  • Candida parapsilosis*
  • Scopulariopsis brevicaulis*
  • Pan-dermatophyte*
  • Internal control
  • *Addtional targets offered in DermaGenius® 3.0 Complete Multiplex real-time PCR kit

DermaGenius® Resistance Multiplex real-time PCR kit (25 rxn) (Cat No.: PN-303)

Targets

  • ‍Trichophyton rubrum / soudanense
  • Trichophyton interdigitale / mentagrophytes
  • Trichophyton mentagrophytes (ITS type IV)
  • ‍Trichophyton tonsurans
  • Trichophyton violaceum
  • Trichophyton quinckeanum / schoenleinii
  • SQLE: Leu393Phe, Phe397Leu, Leu393Ser, Phe397Ile, Phe397Val
  • Internal control

PathoNostics Extraction kit
(Cat No.: PN502)

  • DNA extraction from nail, hair, skin samples in 20 minutes.

PneumoGenius®

Features and benefits

  • Aids in the diagnosis of Pneumocystosis
  • Direct detection in BAL samples
  • Quantification standards included
  • Sample-to-result in less than 3 hours
  • Sulfa drug resistance markers included (DHPS mutations)
  • High sensitivity due to detection of conserved multi copy genes (mtLSU)
  • Clinically validated on BAL samples (published data)

PN-600  PneumoGenius® Multiplex real-time PCR kit (25 rxn) (Cat No.: PN-600)

Targets

  • Pneumocystis jirovecii
  • DHPS mutations (codon 55 and 57)
  • Internal Control (IC)‍
  • Quantification standards:
  • Standard 1: 10000 copies/μl
  • Standard 2: 1000 copies/μl
  • Standard 3: 100 copies/μl
  • Standard 4: 10 copies/μl

MucorGenius®

Features and benefits

  • Aids in the diagnosis of mucormycosis
  • Direct detection in BAL samples
  • Sample-to-result in less than 3 hours
  • Detection of clinically relevant species: undefined Rhizopus spp., Mucor spp., Rhizomucor spp., Lichtheimia spp. and Cunninghamella spp.
  • High diagnostic value resulting in adapted patient management and in therapeutic decisions
  • Can be used in parallel with the AsperGenius® PCR kit (same protocol)

PN-700 MucorGenius® Multiplex real-time PCR (25 rxn) (Cat No.: PN-700)

Targets

  • Pan-Mucormycetes
  • Rhizopus spp.
  • Lichtheimia spp.
  • Cunninghamella spp.
  • Rhizomucor spp.
  • Internal control

CandidaGenius®

Features and benefits

  • To detect and identify Candida auris DNA after nucleic acid extraction from non-invasive swabs
  • Direct identification from ESwab - no culturing required
  • Targets the ITS gene to determine the presence of Candida auris
  • Results in under 1.5 hours
  • Compatible with multiple PCR instruments

CandidaGenius® C. auris screening assay (50 rxn) (Cat No.: PN-900)

Targets

  • Candida auris

Find out more

For more information, please visit the official PathoNostic website.
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